Dr Angela Russell
Dr Angela Russell
Tutorial Fellow in Chemistry
Research Interests
My research interests are in the field of medicinal chemistry. I have a number of multidisciplinary research collaborations in this area including the development of arylamine N-acetyltransferase inhibitors (for the treatment of tuberculosis and cancer; collaboration with E. Sim, Oxford), transcriptional upregulation of utrophin (for the treatment of Duchenne muscular dystrophy; collaboration with K. E. Davies, Oxford), and protein tyrosine phosphatase inhibitors (for the treatment of a variety of disease indications, including cancer; collaboration with S. Knapp, Oxford). All of these projects are ongoing, and in addition I have recently started a number of collaborations involving more fundamental approaches to the development of new pharmacological agents. These include the discovery of chemical modulators of signalling pathways important in development and disease such as Hedgehog and Wnt/Wingless (with J. Briscoe, J-P. Vincent and N. Itasaki, London), Notch and Bone Morphogenetic Protein (with R. Patient, Oxford).
Other Information
I gained my MChem degree from Oxford University in 2000, which included a final year project on the synthesis and evaluation of ion channel mimics under the supervision of Professor Paul Beer. I completed my DPhil in Oxford in 2004 under the joint supervision of Professor Steve Davies and Tim Perera from Yamanouchi plc (now Astellas Pharma Inc.). The main focus of my work was using a pharmacophore modelling approach for the development of novel phosphatase inhibitors but also encompassed the development of novel asymmetric methodologies and the synthesis of molecules of biological importance. In March 2006 I became a Departmental Research Lecturer in Organic Chemistry and in August 2007 was awarded a Research Councils UK Fellowship in Medicinal Chemistry jointly between the Departments of Chemistry and Pharmacology in Oxford.
