Scattered around the Library are several miscellaneous artefacts from various periods. These include:
- A fragment of one of the Oxyrhynchus Papyri (many of which are housed across the road at the Ashmolean Museum). Our fragment is a letter from Flavius Herculanis to a former slave Aplonarion asking why she didn't attend his son's birthday, from the 3rd century A.D.
- A set of 2 globes, one terrestrial, one celestial, made by John Senex of London in 1740. We also have an 18th-century Latin pamphlet on how to use them.
- The Founder's chest, made of iron with an elaborate locking mechanism that still works.
- A cannonball supposedly fired at the College during the Siege of Oxford in the Civil War of the 17th century.
- A bishop's crozier and a walking stick, the latter supposedly used by Archbishop Laud when he ascended the scaffold for his execution.
- Two 17th-century portraits of King Charles I, one made out of wax or resin, the other a micrographic portrait in which the lines that pick out his features are composed of tiny writing (in this case the text of one of the Psalms).
- Eric Gill's sculpture of Tobias and Sarah.
- Medals, a hammer stamp with the initials of Thomas White, some old clogs.
In the 17th century the Laudian Library played host to items of scientific interest. As well as globes there were two skeletons in specially designed cabinets supplied by John Speed (the first anatomy lecturer at Oxford, and son of the mapmaker) who also gave us an illustrated account of how he put them together. By the 18th century these collections had become a jumble of curiosities. As well as the micrographic portrait mentioned above visitors also reported seeing 'a monster lamb with two heads', 'a hat made of cloves', 'a bird of paradise', 'a stone taken from a man's bladder, of a large size' in a silver casket, and other such items. To add to these the antiquary and physician John Pointer, a Fellow of Merton, fell out with his College and deposited his collection of curiosities with St John's. Some of these items still survive in collections outside of the Library. The stone from a man's bladder is now in the College's silver collections and the few remnants of the Pointer collection are deposited with the Museum of the History of Science in Oxford, most notably a chest containing mineral and biological samples (although Pointer's albums of handwritten and printed curiosities remain in the Library as manuscripts 253 and 254). Unfortunately many of the more curious items (the monster lamb, the skeletons, etc.) have disappeared into the mists of time.